Abstract
The bioavailability of sodium salicylate administered in aqueous, glycerin
and oily vehicles was compared in rabbits. Glycerin formulation was
compared with both aqueous and oily formulations using a two - way
crossover test in eight rabbits, in each study. The results indicate that the
oily formulation gave a lower rate of absorption and a greater extent of
absorption than the other formulations. No significant difference in the
rate and extent of absorption was shown between glycerin and aqueous
formulations Possible reasons for the differences are discussed with particular reference to the effects of oils on the gastric emptying rate.