Abstract

Differential electrolytic potentiometry was applied for the determination of ketoconazole (KTZ) in pure and tablets forms. Microtitrations were performed in aqueous and non- aqueous media using gold electrodes, antimony electrodes, and silver electrodes coated with carbon nanotubes. The floating catalyst chemical vapor deposition (FC-CVD) method was used for coating silver electrodes with carbon nanotubes. A micro injector was designed to deliver precise volumes of the titrant at sub micro liter levels. Sharp and clear end points were observed for the aqueous titrations of volumes of 2.0 μL and 4.0 μL of 0.1M standard KTZ. The recovery and relative standard deviation indicate high accuracy and comparable precession of the method compared to standard analysis method. However, in case of the non-aqueous titrations of volumes of 25.0 μL and 50.0 μL of 0.01M standard KTZ samples have been found to show sharp end points. Moreover, the samples required for the analysis are much less than those required for any other analytical method.