الملخص
Cholesteryl ester transfer protein (CETP) is a glycoprotein involved in
transporting lipoprotein particles and neutral lipids between high-density
lipoprotein (HDL) and low density lipoproteins (LDL) and therefore it>s
a proper target for treating dyslipidemia and related disorders, Guided
by our previously-reported pharmacophore and QSAR models for CETP
inhibition, we synthesized and bio assayed a series of toluene-4-sulfonic
acid 4-benzylamino-phcnyl ester (8a-8m)/ N-(4-benzyl-phenyl)-4-methyl-
benzene sulfonamide (6a-61) derivatives. The proposed structures for
compounds 6a-1 and 8a-m were confirmed via elemental analyses, IR
spectroscopy. mass spectroscopy, lH- and 13C-NMR spectra. The most
potent synthesized compound 6j illustrated anti-CETP ICSO 0f 3.4 uM.