Al-Balqa Journal for Research and Studies

Published by: Deanship of Scientific Research, Al-Ahliyya Amman University

ISSN (Print Version): 1684-0615, ISSN (Online Version): 2616-2814

Open Access Journal

Protective Effects of Antioxidants Against Rheumatoid Arthritis-Induces Lipid Peroxidation and Glutathione Depletion


Volume 6, Issue No 2, 1999

Pages: 45 - 61

Number of Views:



Abstract

The effects of rheumatoid arthritis (RA) and antioxidant therapy for 10 days with vitamin E, Vitamin C and vitamin A on serum lipid peroxidation (MDA content), glutathione (GSH) content, glutathione S-transferase (GST) activity, glutathione reductase (GSR) activity, both total and selenium dependent glutathione peroxidase (GSI-I-Px) activities were tested in 18 rheumatic patients. RA patients had increased MDA content, and index of lipid peroxidation, depleted GSH levels, elevated GST activity and inhibited GSR and GSI-I-GSI-I-Px activities, as compared to 20 healthy subjects. Supplementation with vitamin E decreased MDA content, elevated GSI-I levels, GSR and GSI-I-Px activities after 5 days of therapy. Vitamin C supplementation did so only after 10 days of therapy, while treatment with vitamin A showed no significant changes in these parameters compared to pretreatment levels The results suggest that antioxidant therapy may afford some protection against oxidative stress associated with RA



Keywords

Effects -Antioxidants.


Subjects


Citation

Hadi, R. &  

Al-Rawi, Z. &  

Hassan, M.

  (1999).

  Protective Effects of Antioxidants Against Rheumatoid Arthritis-Induces Lipid Peroxidation and Glutathione Depletion.

  Al-Balqa Journal for Research and Studies,

  6

(2),

  45-

61.