Al-Balqa Journal for Research and Studies

Published by: Deanship of Scientific Research, Al-Ahliyya Amman University

ISSN (Print Version): 1684-0615, ISSN (Online Version): 2616-2814

Open Access Journal

Effects of Oily Vehicles on the Bio-availability of Orally Administered, Sodium Salicylates in Rabbit.


Volume 9, Issue No 2, 2002

Pages: 73 - 85

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Abstract

The bioavailability of sodium salicylate administered in aqueous, glycerin and oily vehicles was compared in rabbits. Glycerin formulation was compared with both aqueous and oily formulations using a two - way crossover test in eight rabbits, in each study. The results indicate that the oily formulation gave a lower rate of absorption and a greater extent of absorption than the other formulations. No significant difference in the rate and extent of absorption was shown between glycerin and aqueous formulations Possible reasons for the differences are discussed with particular reference to the effects of oils on the gastric emptying rate.



Keywords

Sodium Salicylate, Gastric Emptying Rate (GER) , Bio-availability.


Subjects


Citation

Alhamami, O.

  (2002).

  Effects of Oily Vehicles on the Bio-availability of Orally Administered, Sodium Salicylates in Rabbit..

  Al-Balqa Journal for Research and Studies,

  9

(2),

  73-

85.